Background and aim: In spite of approval of new therapeutic modalities, the clinical outcome of patients with acute myeloid leukemia (AML) remains unsatisfactory. Accurate risk stratification of patients is crucial for improving their outcome. Programmed death receptor-ligand 1 (PD-L1) plays an important role in the progression of malignant disorders. So we aimed to analyze PD-L1 expression on AML cells by flow cytometry and its relation to post induction response.