We found that right and left-sided colon cancers are different from each other in terms of age at diagnosis, presenting symptoms, aim of surgery, stage at diagnosis, response to first-line chemotherapy, and causes of death. Several recent international studies support the findings of our work and nowadays there is a global trend towards considering right and left-sided colon cancer as two distinct disease entities. Further research and multi-institutional studies should be done worldwide for providing more evidence of the impact of colon cancer sidedness with special emphasis on molecular phenotype and effect of targeted therapy and immunotherapy on survival outcomes.