NULLTo assess the postoperative analgesic efficacy of epidural dexmedetomidine added to bupivacaine infusion for patients undergoing major abdominal cancer surgery. Methods: Patients scheduled for major upper abdominal cancer surgery were allocated to group bupivacaine (n =32), in which patients received epidural bupivacaine infusion (6 mL/h bupivacaine 0.1%) for 48 hours postoperatively, or group bupivacaine + dexmedetomidine )=32), in which patients received epidural dexmedetomidine added to bupivacaine infusion (6 mL/ of bupivacaine 0.1% + dexmedetomidine, 0.5 μg/mL) for 48 hours postoperatively. The cumulative morphine consumption, the time to first analgesic request, and the VAS painةscore were evaluated. Results: The cumulative morphine consumption was significantly reduced in group bupivacaine+ dexmedetomidine compared with group bupivacaine: mean ± SD of 10.40±5.16 mg vs23.23±8.37mg with an estimated difference (95% CI) of –12.83 (−16.43, –9.24), (P0.001(.The time to the first analgesic demand was significantly delayed in group bupivacaine + dexmedetomidine compared with group bupivacaine: median (IQR) of 6 (1.75, 8.25) h vs 1 (0, 4)h, P0.001). The mean collapsed over time of overall VAS pain scores at rest and movement was significantly reduced in group bupivacaine + dexmedetomidine compared with group bupivacaine:mean ± SE of 1.6±0.08 vs 2.38±0.08 with an estimated difference (95% CI) of −0.8(−1, –0.86), (P0.001), and mean ± SE of 2.17±0.07 vs 3.25±0.07 with an estimated difference(95% CI) of −1.1 (−1.27, – 0.89), (P0.001), respectively. Conclusion: Epidural infusion of dexmedetomidine added to bupivacaine for patients undergoing major abdominal cancer surgery significantly reduced morphine consumption, delayed time to first analgesic supplementation, and decreased pain intensity during the first 48 hours postoperatively without harmful derangement on hemodynamics.