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Influence of intraoperative radiation therapy on locally advanced and recurrent colorectal tumors: A 16-year experience

ملخص البحث
Background: Intraoperative radiation therapy (IORT) has been proposed as a tool to improve local control in patients with locally advanced primary or recurrent colorectal cancer. Methods: A retrospective review (1999e2015) of all patients undergoing IORT for locally advanced or recurrent colorectal cancer at a single academic center was performed. Patient demographics, oncologic staging, short-term and long-term outcomes were reviewed. Results: There were 77 patients (mean age 63 ± 11 years) identified, of whom 19 had colon cancer, 57 had rectal cancer, and 2 had appendiceal cancers. R0 resection was performed in 53 patients (69%), R1 in 19 (25%) and R2 in 5 (6%). Ten (13%) patients had a local recurrence at 18 ± 14 months and 34 (44%) had a distant recurrence at 18 ± 18 months. Mean survival was 47 ± 41 months. Conclusion: IORT resulted in low local failure rates and should be considered for patients with locally advanced or recurrent colorectal cancers.
مؤلف البحث
Justin T. Brady a, Benjamin P. Crawshaw a, Barrington Murrell b, Eslam M.G. Dosokey a, Murad A. Jabir a, Scott R. Steele a, Sharon L. Stein a, Harry L. Reynolds Jr a, *
مجلة البحث
The American Journal of Surgery
مؤلف البحث
Eslam Mohammed Gaber Desoky
صفحات البحث
pp. 586 - 589
الناشر
NULL
تصنيف البحث
1
عدد البحث
Vol. 213
موقع البحث
NULL
سنة البحث
2017