The present study aimed to investigate the effect of two levels of carob powder 10 and 20%on lipid profile.Forty maleSprague–Dawleyratsweredividedintotwogroups.The first group was fed on a basal diet and acts as a control group. The second group was fed on a hyperlipidemic diet (a basal dietplus10% animalfatand1% cholesterol).After6weeks, the secondgroup was divided intothree evensubgroups:subgroup 1 was fed ona hyperlipidemicdiet, subgroup2 was fed on a hyperlipidemic diet plus 10 % carob powder, and subgroup 3 was fed on a hyperlipidemic diet plus 20 % carob powder.Attheendoftheexperimentalperiod,serumsamples were collected to measure total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very-low-density lipoproteins (VLDL). Heart and kidney samples were taken for histopathological examination. The obtained results revealed that feeding rats with10and20%carobpowderimprovedlipidprofileparametersandhistopathologicalcharacteristicsintheheartandkidney of experimental rats