Experimental rupture of the urinary bladder was conducted in four rams. Blood, urine and abdominal fluid samples were collected before and at regular intervals following the opera¬tion till death. Besides, heart, liver and kidney tissue samples were examined microsco¬pically. The study revealed:¬ 3-Small few foci of fibrinous inflammation with degeneration in the myocardium, tub¬ular nephrosis with some glomerular changes and centrilobular hepatic necrosis with congestion of the intestine. 4-Progressive elevation of blood urea nitro¬gen, non-protein nitrogen, serum creatinine serum inorganic phosphorus and serum potassium level in relation to time post-operation. Serum, sodium and chloride levels behaved on the contrary. Similar data were achieved in urine and abdominal fluid sam¬ples