The study included that 35 clinically infected cattle were subjected for the clinical therapeutic trail. The age of these animals ranged from one day to above five years old. In the clinical therapeutically trail we used BUPAQUONE® as a new drug for treatment of tropical theileriosis it gave 91.4 % as an accuracy rate in general but if the diseased animals detected and treated as early as possible the accuracy rate reached 100%, in cases that complicated with respiratory signs the accuracy rate depended on the type of antibiotic that used as a treatment for control of the respiratory affection. Cases that received BUPAQUONE with Oxyteteracycline hydrochlorid as antibiotic therapy for diseased animals the accuracy rate was 81.8% but in cattle that received BUPAQUONE with Marbofloxacine as antibiotic therapy the accuracy rate was 93.3%. So we can conclude that Marbofloxacine is more preferred as antibiotic treatment in cases of tropical theileriosis that suffered from respiratory signs. We concluded that, Bupaquone® is recommended as a treatment for tropical theileriosis but in some cases that are complicated with respiratory signs using of antibiotics are recommended such as Marbofloxacine 10% which recorded higher rate of recovery than Oxyteteracycline 20% long acting in control of respiratory complication of the tropical theileriosis