The present work rationalizes the construction of a cutting-edge electrochemical sensor and its utilization in establishing the unique square wave voltammetric (SWV) procedure for the concurrent analysis of a ternary mixture of anti-Parkinson drugs (L-dopa (LVD), Carbidopa (CRD), and Istradefylline (ISF)) in bulk forms and plasma specimens. The sensor, denoted as TbNPs@poly-PRS/PGE, was designed which based on terbium nanoparticles (TbNPs) decorated Pyrosin (PRS) stain polymer platform on the surface of pencil graphite electrode (PGE). The improved electrochemical efficiency and morphological features of the sensor was assured through various investigations including cyclic voltammetry, scanning electron microscopy, electrochemical impedance spectroscopy, and theoretical computational modelling. This sensor was devoted to electrooxidization and simultaneous quantitation of LVD-CRD-ISF …