Background

The hippocampus is a brain structure that plays important roles in the acquisition of new memories. Dichlorvos or 2, 2-dichlorovinyl dimethyl phosphate (DDVP) is an organophosphate compound that is toxic to the hippocampus. Vitamin E is an antioxidant.

Aim

To evaluate the potential ameliorating effect of vitamin E supplementation on dichlorvos (DDVP)-induced toxicity in the hippocampus of male albino rat.

Materials and methods

In total, 40 male-adult rats aged 3 months were divided into five groups: group A (control): they received no treatment. Group B (treated): DDVP given at a dose of 2.5 mg/kg body weight/day for 4 weeks. Group C (protective): DDVP at the same previous dose cotreated with vitamin E at a dose of 200 mg/kg body weight/day for 4 weeks. Group D (therapeutic): DDVP given at the same previous dose for 4 weeks. Post-DDVP administration, rats were further treated with vitamin E at …