ABSTRACT

The purpose of this study was carried out to examine the expression of PCNA, P53 and survivin in different types of ameloblastoma. The cases of ameloblastoma consisted of solid type tumors and histologic arrangements of different subtypes were observed. In some cases, more than one histologic subtype was identified in the same lesion, and each tumor was categorized according to the predominant cell pattern. PCNA and survivin immunohistochemical expression revealed stronger staining for the follicular ameloblastoma, while for p53 protein the strongest stain was detected in the plexiform type. The results indicated that the ameloblastoma has great proliferative potential, which can contribute to explain its aggressiveness and invasive characteristics