ABSTRACT

To analyze whether the S-phase fraction (SPF) may contribute to prognosis of similarly staged tongue squamous cell carcinoma, DNA flow cytometric data from 30 cases of tongue squamous cell carcinoma were analyzed. The SPF values ranged between 2.30% and 34.32% (mean 10.92%). SPF was calculated and correlated with the disease free survival rate and the overall survival of the patients. By multivariate survival analysis, SPF was significantly associated with the disease free survival rate and the overall survival of patients (P < 0.05). The results indicate that SPF has a relevant prognostic power for tongue squamous cell carcinoma.