Abstract Adult Damascus does (n=18) were used in this experiment to investigate the relationship of Damascus’s does estrous activity (EA) to body weight (BW), body measurements (BM) and progesterone profile (P4) across seasons. Results indicated that season had significant effects on estrous activity, P4 level, BW and BM. Estrous percentage, estrous duration (ED), normal estrous cycle (EC), and P4 concentration decreased significantly with decreasing BW and some BM. ED increased with increasing normal EC. Short and long EC increased respectively in autumn and summer. P4 levels varied significantly among the three EC types and was influenced significantly by season during pro-estrus and di-estrus phases. Positive correlations occurred between (P4 level, ED and EC) and (BW and some BM). Conclusion, BW and some BM may be used as good criteria in raising the reproductive performance of farm animals, further, Damascus does displayed their maximal hormonal and estrus activity in autumn and winter.