The main objective of this paper is to detect spatial and socio-economic changes in Shoeshai village, Ashmoon district, Menoufiah governorate, Egypt through the period 1930 – 2012. GIS Arc Map 10 was applied using the village maps obtained from Google Earth and other secondary sources. 2120 buildings of the village were identified and surveyed. Data concerning different aspects of change were gathered using pre-constructed questionnaires. SPSS was used for data processing and analysis. Results showed that great changes have occurred in different spatial and socio-economic aspects. Some of these changes may reflect improvements occurred in standard of living of Shoeshi inhabitants. Some other changes may have negative effect on agricultural sustainability of the village. Great efforts are needed to be devoted by the government and the extension organization to encourage people to conserve agricultural lands in order to achieve agricultural sustainability in Egypt.