This experiment was carried out at Orchard, Faculty of Agriculture, Assiut University, in 2017 and 2018 seasons to study the effect of chitosan at 0.5, 1 and 2%, calcium chloride (CaCl2) at the rate of 2, 4 and 6% and Gibberellic acid (GA3) at 25, 50 and 100 ppm on cracking and fruit quality of "Manfalouty" pomegranate. The experiment was set in a Randomized complete block design (RCBD) with three replicates per treatment, one tree each. The results indicated that all treatments significantly decreased the fruit cracking and improved the yield and fruit quality comparing with control. No significant differences were found between chitosan, GA3 or calcium chloride at any used concentrations. It could be concluded that spraying either chitosan at 0.5%, GA3 at 50 ppm or CaCl2 at 2% twice on mid of June and August effectively reduced cracking and improve the yield and fruit quality on "Manfalouty" pomegranate.