Background: Signet ring cell carcinoma (SRC) of the stomach is a histological type based on microscopic characteristics. SRC's clinicopathological characteristics and prognosis are still controversial. This study compared the clinicopathological features and prognosis of patients with SRC carcinoma with those with nonsignet ring cell carcinoma of the stomach (NSRC) Patients and methods: We retrospectively analyzed data from 109 patients who had gastric carcinoma, including 30 SRC and 79 NSRC. Results: No significant differences existed with respect to age, tumour size, depth of invasion and lymph node metastasis between the patients with SRC histology and NSRC. The overall survival not affected by different histopathological types of gastric carcinoma (P= 0.699). Conclusion: Patients with SRC histology do not have a worse prognosis than those with NSRC. [Khalid Rezk, Hanan Ahmed Mohammed, Mayada Fawzy Sedik, Ahmed Refaat Abd Elzaher and Shimaa H. Shaban. Signet ring carcinoma of the stomach: impact on prognosis and outcome. Cancer Biology 2018;8(3):9-13]. ISSN: 2150-1041 (print); ISSN: 2150-105X (online). http://www.cancerbio.net. 2. doi:10.7537/marscbj080318.02.