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Diagnostic potential of serum humanin in breast cancer among the Egyptian population

ملخص البحث

Abstract Background Globally, breast cancer is the most frequently diagnosed malignancy and the second leading cause of cancer-related mortality among women. The ongoing pursuit of early detection has driven interest in identifying and validating novel diagnostic biomarkers that could enhance prognosis and therapeutic outcomes. Humanin, a mitochondrial-derived peptide (MDP) with reported cytoprotective properties, has been implicated in cancer biology and may play a role in breast cancer pathogenesis. Methods A total of 75 female patients with primary non-metastatic breast cancer and 70 age-matched healthy controls of comparable age were enrolled in this study. Serum concentrations of humanin were quantified using an enzyme-linked immunosorbent assay (ELISA). Results Serum humanin concentrations were significantly elevated in breast cancer patients compared with healthy controls (p < 0.001). Receiver operating characteristic (ROC) curve analysis demonstrated that humanin effectively differentiated breast cancer patients from controls, with a sensitivity of 78.7% and specificity of 62.9%. Conclusion These findings suggest that humanin could serve as a promising biomarker for breast cancer screening and early detection. Further large-scale studies are warranted to validate its diagnostic potential and establish its clinical utility. Keywords Breast cancer, Humanin, Mitochondrial-derived peptides, Biomarker

مؤلف البحث
Maha H. Mohamed1*, Walaa Talaat Kamel1, Eman H. Ibrahim1*, Ahmed Makboul1*, Amany Nasr Elemary2 and Doaa A. Mohammed1
تاريخ البحث
مستند البحث
مجلة البحث
Discover Oncology
الناشر
springer nature
عدد البحث
16
سنة البحث
2026